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        4-Aminopyridine

        4-Aminopyridine
        4-Aminopyridine structure
        CAS No.
        504-24-5
        Chemical Name:
        4-Aminopyridine
        Synonyms
        4APY;4-AP;mi-w-3;AMpyra;EL 970;avitrol;vmi10-3;Neurelan;Prc 1237;VMI 10-3
        CBNumber:
        CB9853687
        Molecular Formula:
        C5H6N2
        Formula Weight:
        94.11
        MOL File:
        504-24-5.mol

        4-Aminopyridine Properties

        Melting point:
        157 °C
        Boiling point:
        273 °C(lit.)
        Density 
        1.26
        refractive index 
        1.5560 (estimate)
        Flash point:
        156°C
        storage temp. 
        0-6°C
        solubility 
        H2O: soluble50mg/mL, clear, colorless
        pka
        9.114(at 25℃)
        form 
        Crystalline Powder, Solid or Crystals
        color 
        White to faint grey to light yellow
        Water Solubility 
        Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
        Merck 
        14,3933
        BRN 
        105782
        InChIKey
        NUKYPUAOHBNCPY-UHFFFAOYSA-N
        CAS DataBase Reference
        504-24-5(CAS DataBase Reference)
        NIST Chemistry Reference
        4-Pyridinamine(504-24-5)
        EPA Substance Registry System
        4-Aminopyridine (504-24-5)
        SAFETY
        • Risk and Safety Statements
        Symbol(GHS) 
        GHS06,GHS07,GHS08,GHS09
        Signal word  Danger
        Hazard statements  H335-H401-H311-H315-H319-H370-H372-H411-H300
        Precautionary statements  P260-P264-P270-P273-P280-P301+P310+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P307+P311-P391-P405-P501-P280h-P301+P310-P302+P352-P305+P351+P338
        Hazard Codes  T+,N,T,Xi
        Risk Statements  28-36/37/38-51/53-23/24/25
        Safety Statements  26-36/37/39-45-60-61-37/39-28A-1
        RIDADR  UN 2671 6.1/PG 2
        WGK Germany  3
        RTECS  US1750000
        8-21
        Autoignition Temperature 640 °C
        Hazard Note  Toxic/Irritant
        TSCA  Yes
        HazardClass  6.1
        PackingGroup  II
        HS Code  29333999
        Toxicity LD50 orally in Rabbit: 21 mg/kg
        NFPA 704
        1
        3 0

        4-Aminopyridine price More Price(20)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 275875 4-Aminopyridine ≥99% 504-24-5 1g $28.2 2019-12-02 Buy
        Sigma-Aldrich 1162454 Dalfampridine United States Pharmacopeia (USP) Reference Standard 504-24-5 200mg $352.8 2019-12-02 Buy
        TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 25g $25 2019-12-02 Buy
        TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 100g $78 2019-12-02 Buy
        Alfa Aesar A12405 4-Aminopyridine, 98% 504-24-5 50g $55.3 2019-12-02 Buy

        4-Aminopyridine Chemical Properties,Uses,Production

        Description

        Dalfampridine (also referred to as 4-AP) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
        From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.

        Chemical Properties

        WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

        Chemical Properties

        4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.

        Chemical Properties

        4-Aminopyridine is white to tan or brown crystalline material. Odorless.

        Originator

        Rush University Medical Center (United States)

        Uses

        vasodilator

        Uses

        Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

        Definition

        ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.

        brand name

        Neurelan (E′lan);Ampyra.

        General Description

        White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

        Reactivity Profile

        4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

        Health Hazard

        Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.

        Health Hazard

        4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks

        Fire Hazard

        Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

        Safety Profile

        Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.

        Potential Exposure

        Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison

        Shipping

        UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

        Purification Methods

        Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]

        Incompatibilities

        Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.

        Waste Disposal

        Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.

        4-Aminopyridine Preparation Products And Raw materials

        Raw materials

        Preparation Products


        4-Aminopyridine Suppliers

        Global( 400)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Hangzhou Cyanochem Co., Ltd. 17788583750
        +86 571 85220831 info@cyanochem.com China 276 58
        Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318
        4000311741 master@sjzsdyn.com China 6604 58
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76
        3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
        86-21-50328109 3bsc@sina.com China 15881 69
        Alfa Aesar 400-610-6006; 021-67582000
        021-67582001/03/05 saleschina@alfa-asia.com China 30163 84
        TAIYUAN RHF CO.,LTD. +86 351 7031519
        +86 351 7031519 sales@RHFChem.com China 2348 56
        TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
        021-67121385 Sales-CN@TCIchemicals.com China 24555 81
        ShangHai DEMO Chemical Co.,Ltd 400-021-7337 qq:2355568890
        0086-21-50182339 sales@demochem.com; export1@demochem.com China 2584 57
        Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820
        86 (10) 60270825 dtftchem@sina.com China 3393 62
        Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
        0086-571-85864795 sales@capotchem.com China 18228 66

        View Lastest Price from 4-Aminopyridine manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2018-07-23 4-Aminopyridine
        504-24-5
        US $63.50 / KG 1KG 98% 100ton career henan chemical co

        4-Aminopyridine Spectrum


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