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        Dextran Sulfate Sodium Salt

        Description Uses Toxicity
        Dextran Sulfate Sodium Salt
        Dextran Sulfate Sodium Salt structure
        CAS No.
        9011-18-1
        Chemical Name:
        Dextran Sulfate Sodium Salt
        Synonyms
        asuro;dexnon;ds-m-1;dexulate;Ccris 196;dextrarine;DEXSATEMPO(TM);DEXTRALIP(R) 50;DEXTRAN SULFATE;DEXTRAN SULPHATE
        CBNumber:
        CB9339022
        Molecular Formula:
        (C6H7Na3O14S3)n
        Formula Weight:
        0
        MOL File:
        Mol file

        Dextran Sulfate Sodium Salt Properties

        storage temp. 
        2-8°C
        solubility 
        H2O: 100 mg/mL
        form 
        powder
        color 
        White to off-white
        PH
        pH(50g/l, 25℃)4.5~8.0
        Water Solubility 
        Soluble in water.
        Merck 
        2951
        EPA Substance Registry System
        Dextran, hydrogen sulfate, sodium salt (9011-18-1)
        SAFETY
        • Risk and Safety Statements
        Hazard Codes  Xi,Xn
        Risk Statements  20/21/22-36/37/38
        Safety Statements  26-36-37/39-24/25
        WGK Germany  2
        RTECS  HH9290000
        3-10
        TSCA  Yes
        HS Code  39139000

        Dextran Sulfate Sodium Salt price More Price(70)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade 9011-18-1 50gm-m $221 2019-12-02 Buy
        Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade 9011-18-1 10gm-m $66.6 2019-12-02 Buy
        TCI Chemical D5143 Dextran Sulfate Sodium from Dextran of Mw. Approx. 8000 9011-18-1 25g $576 2019-12-02 Buy
        TCI Chemical D5144 Dextran Sulfate Sodium from Dextran of Mw. Approx. 40000 9011-18-1 25g $576 2019-12-02 Buy
        Alfa Aesar J14489 Dextran sulfate sodium salt, Affymetrix/USB 9011-18-1 50g $138 2019-12-02 Buy

        Dextran Sulfate Sodium Salt Chemical Properties,Uses,Production

        Description

        Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
        With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
        Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
        Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.

        Uses

        1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
        2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
        3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

        Toxicity

        The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
        More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

        Chemical Properties

        White to off-white powder

        Uses

        Clinical reagent (HDL cholesterol determination).

        Uses

        Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.

        Dextran Sulfate Sodium Salt Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Dextran Sulfate Sodium Salt Suppliers

        Global( 191)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Beijing NuoqiYa Biotechnology Co., Ltd. 4000-819-385 010-62329685 13718666987
        010-62340519 good@nuoqiya.com China 1973 55
        Herbon International Polysaccharide Biotechnology (Heyuan) Co. Ltd. 0762 3499803;18027990213
        - 2141594860@qq.com China 3 68
        Hubei XinghengKang Chemical Technology Co., Ltd. 027-88878869-
        027-88878869 xhkhu2014@163.com; China 213 58
        Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366-
        0755-85201366 sales@regentsciences.com; China 8120 58
        Zhejiang Lianshuo Biotechnology Co., Ltd. 18616526224
        lianshuo@vip.126.com China 4821 58
        Shanghai Jizhi Biochemical Technology Co. Ltd. 400-900-4166
        3007522970@qq.com China 52519 58
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76
        Meryer (Shanghai) Chemical Technology Co., Ltd. 21-61259100-
        86-21-61259102 sh@meryer.com China 40268 62
        3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
        86-21-50328109 3bsc@sina.com China 15881 69
        Energy Chemical 021-58432009 / 400-005-6266
        021-58436166-800 info@energy-chemical.com China 44026 61

        Related articles


        View Lastest Price from Dextran Sulfate Sodium Salt manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2018-12-21 Dextran Sulfate Sodium Salt
        9011-18-1
        US $8.00 / kg 1kg 99% 10MT career henan chemical co
        2017-12-08 Dextran Sulfate Sodium Salt
        9011-18-1
        US $1.00 / UG 1UG >98% 12 tonnes Herbon International Holdings Company Limited

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