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        Melatonine

        description Chemical properties Uses Physiological functions Synthesis of Melatonin
        Melatonine
        Melatonine structure
        CAS No.
        73-31-4
        Chemical Name:
        Melatonine
        Synonyms
        MLT;MLK7;MLT1;primex;mlklak;Circadin;Melovine;MELATONIN;melotonin;MELATONINE
        CBNumber:
        CB5364927
        Molecular Formula:
        C13H16N2O2
        Formula Weight:
        232.28
        MOL File:
        73-31-4.mol

        Melatonine Properties

        Melting point:
        116.5-118 °C(lit.)
        Boiling point:
        374.44°C (rough estimate)
        Density 
        1.1099 (rough estimate)
        refractive index 
        1.6450 (estimate)
        Flash point:
        9℃
        storage temp. 
        -15°C
        solubility 
        Soluble in ethanol to at least 50mg/ml
        pka
        16.26±0.46(Predicted)
        form 
        Powder
        color 
        white to off-white
        Merck 
        14,5816
        BRN 
        205542
        InChIKey
        DRLFMBDRBRZALE-UHFFFAOYSA-N
        CAS DataBase Reference
        73-31-4(CAS DataBase Reference)
        NIST Chemistry Reference
        Melatonin(73-31-4)
        SAFETY
        • Risk and Safety Statements
        Symbol(GHS) 
        GHS02,GHS06,GHS08
        Signal word  Danger
        Hazard statements  H225-H301+H311+H331-H370
        Precautionary statements  P210-P260-P280-P301+P310-P311
        Hazard Codes  T,F
        Risk Statements  60-39/23/24/25-23/24/25-11
        Safety Statements  24/25-99-53-45-36/37-16-7
        RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
        WGK Germany  2
        RTECS  AC5955000
        8-10-23
        HS Code  29379000
        Toxicity LD50 orally in Rabbit: > 3200 mg/kg

        Melatonine price More Price(18)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 444300 Melatonin 73-31-4 1gm $75.2 2019-12-02 Buy
        Sigma-Aldrich 1380105 Melatonin United States Pharmacopeia (USP) Reference Standard 73-31-4 150mg $335.65 2019-12-02 Buy
        TCI Chemical M1105 Melatonin >98.0%(HPLC)(N) 73-31-4 1g $51 2019-12-02 Buy
        TCI Chemical M1105 Melatonin >98.0%(HPLC)(N) 73-31-4 5g $153 2019-12-02 Buy
        Alfa Aesar J62452 Melatonin, 99+% 73-31-4 25g $122 2019-12-02 Buy

        Melatonine Chemical Properties,Uses,Production

        description

        Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.

        Chemical properties

        White or almost white crystalline powder.

        Uses

        1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.
        2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.
        3. Biochemical research.

        Physiological functions

        1. The effect to brain: the melatonin obtained by brain mainly gathers in midbrain and hypothalamus and it adds the activity of brain pyridoxal kinase, thus promoting glutamic acid decarboxylation to γ-amino butyric acid, 5-hydroxytryptophane decarboxylation to 5-hydroxytryptamine, both of which can inhibit the increase of the neurotransmitter content and have an effect of adjustment and mitigation on central nervous system.
        2. The effect to hypothalamus and pituitary: materials like polypeptide produced by pineal body still have thyrotropin-releasing hormone(TRH) and luteinizing hormone releasing hormone(LRH) which are same with what hypothalamus produces except AVT. After injection of melatonin, gonadotropin (GnH)(FSH,LH) and melanocyte stimulating hormone(MSH) are lowered while growth hormone increases. Cutting pineal gland will cause pituitary hypertrophy, increase pituitary secretion and lower prolactin(PRL) and antidiuretic hormone (ADH).
        3. The relation to gonad: melatonin has an inhibitory effect on the reproductive system. Clinically, main cytoma of pineal body can lead to pubertal delay and when teratoma appears in pineal body, it may result in sexual precocity because main cells are excluded. Ambient light and sympathetic nerve can affect the function of the reproductive system by inhibiting the synthesis and release of melatonin in pineal gland.
        4. The relation to thyroid: by injecting melatonin, thyroid secretion will decrease. This may be caused through the inhibition of the hypothalamus release and Thyroid Stimulating Hormone (TSH) secretion of pituitary, hence holding back the function of thyroid.
        5. The relation to adrenal cortex: melatonin has a strong inhibitory effect on adrenal cortex. If we inject pineal body extracts to healthy people, we will find that their aldosterone secretion and 17-ketosteroid output will decrease.
        6. The relation to pancreatic island: melatonin can lower blood glucose and increase sugar tolerance. In conclusion, pineal gland can assist pituitary to jointly adjust endocrine function and play an vital role in keeping relatively constant in body environment and controlling some endocrine function, especially for gonad.

        Synthesis of Melatonin

        Pineal cells obtain tryptophan from blood circulation and become 5-hydroxytryptophane catalyzed by hydroxylase and 5-hydroxytryptophane turns into 5-hydroxytryptamine after decarboxylated by decarboxylase. There are three possible changes for 5-hydroxytryptamine: for the first part it may turn into 5-hydroxyl-benzpyrole acetic acid when deaminated by monoamine oxidase; for another part, some 5-hydroxytryptamine will leave the pineal cell and be taken in by sympathetic nerve ending and stored with neurotransmitter and noradrenalin; for the remaining part, the 5-hydroxytryptamine will be acetylated by N-acetyl-5-hydroxy tryptamine transferase and then be o-methoxy by hydroxylation indole-o-methyl converzyme, finally forming melatonin. After being synthesized, melatonin will be released by cells and enter into blood circulation through cerebrospinal fluid or directly, where noradrenalin may strengthen the synthesis, the speed of which depends on activity of hydroxylase in liver microsomes. Catalyzed by the hydroxylase, 6-hydroxylmelatonin is formed, soon afterwards it combines with glucuronic acid and sulfate, excreting through urine.

        Chemical Properties

        Off-White Powder

        Uses

        Melatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger

        Uses

        Immunostimulant;Melatonin receptor ligand

        Uses

        Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

        Uses

        Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase

        Definition

        ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.

        World Health Organization (WHO)

        Melatonin is promoted as a cure for travel sickness, jet-lag and insomnia and has recently been claimed in the United States to reverse the ageing process. A synthetic version has been freely available from health food shops and pharmacies as a "nutritional supplement" since 1993.

        Biological Activity

        Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .

        Veterinary Drugs and Treatments

        Melatonin may be useful to treat Alopecia-X in Nordic breeds, canine pattern baldness, or canine recurrent flank alopecia in dogs. It has been used anecdotally for the treatment of sleep cycle disorders in cats and geriatric dogs and to treat phobias and separation anxiety in dogs. Melatonin implants are used in the mink and fox pelt industries to promote the development of luxurious hair coats. Implants are also used to improve early breeding and ovulation rates in sheep and goats. Preliminary research is being done for this purpose in horses also.
        In pigs, one study (Bubenik, Ayles et al. 1998) demonstrated that 5 mg/kg in feed reduced the incidence of gastric ulcers in young pigs.

        Melatonine Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Melatonine Suppliers

        Global( 469)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Huanggang Saikang Pharmaceutical Co.,Ltd +86-713-8667500
        +86-713-8672800 hgsaikang@163.com CHINA 1 58
        Shanghai ChengShao Biological Technology Co., Ltd. 021-61847300 13341622919
        021-61847300 shcss01@163.com China 4810 58
        Shanghai EFE Biological Technology Co., Ltd. 021-65675885
        021-65675885 info@efebio.com China 9935 58
        Shenzhen Barker Chemical Technology Co., Ltd. 18825257575
        0755-35352037 3535203737@qq.com China 308 58
        Hubei Hongjing Chemical Co., Ltd. 027-82333386-
        86-027-82333386 617019505@qq.com; China 275 58
        Taizhou Bona Chemical Co., Ltd. 15157283298
        kitty@tzbnchem.com CHINA 25 58
        Wuhan Runzeweiye Technology Co., Ltd. 027-50779735-
        027-50779735 runzeweiye999@163.com; China 806 55
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76
        Nanjing Elegant Nutraceuticals Co., Ltd 0086-25-83241153, 83241163
        0086-25-83241173 sales@elegantnutri.com China 51 55
        Meryer (Shanghai) Chemical Technology Co., Ltd. 21-61259100-
        86-21-61259102 sh@meryer.com China 40268 62

        View Lastest Price from Melatonine manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2019-07-05 Melatonine
        73-31-4
        US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
        2019-11-28 Melatonine
        73-31-4
        US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
        2019-10-31 Melatonin
        73-31-4
        US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD

        Melatonine Spectrum


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