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        Sodium hyaluronate

        Physicochemical property Sodium Hyaluronate Injection Application in Particular Diseases Pharmacological action Pharmacodynamics Pharmacokinetics Clinical application Usage dosage Adverse reaction Precautions Uses
        Sodium hyaluronate
        Sodium hyaluronate structure
        CAS No.
        9067-32-7
        Chemical Name:
        Sodium hyaluronate
        Synonyms
        Sph;HA-AM;HA-SHL;HA-AML;Healon;Oegehd;Equron;Opegan;Si-4402;Sl-1010
        CBNumber:
        CB4176691
        Molecular Formula:
        C14H22NNaO11
        Formula Weight:
        403.31
        MOL File:
        9067-32-7.mol

        Sodium hyaluronate Properties

        alpha 
        D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951)
        storage temp. 
        −20°C
        solubility 
        H2O: 5 mg/mL, clear, colorless
        form 
        Powder
        color 
        White to cream
        PH
        pH(2g/l,25℃) : 5.5~7.5
        Water Solubility 
        SOLUBLE
        Merck 
        13,4776
        Stability:
        Stable. Incompatible with strong oxidizing agents.
        InChIKey
        MAKUBRYLFHZREJ-JWBQXVCJSA-M
        CAS DataBase Reference
        9067-32-7(CAS DataBase Reference)
        SAFETY
        • Risk and Safety Statements
        Hazard Codes  B,Xi
        Risk Statements  36/37/38
        Safety Statements  22-24/25-36/37/39-27-26
        WGK Germany  3
        RTECS  MT7250000
        3-10
        HS Code  39139000
        Toxicity LD50 oral in rabbit: > 1gm/kg
        NFPA 704
        0
        0 0

        Sodium hyaluronate price More Price(51)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 02737 Hyaluronic acid sodium salt from Streptococcus equi mol wt 1,750,000-2,000,000 9067-32-7 10mg $160 2019-12-02 Buy
        Sigma-Aldrich 02737 Hyaluronic acid sodium salt from Streptococcus equi mol wt 1,750,000-2,000,000 9067-32-7 50mg $611 2019-12-02 Buy
        Alfa Aesar J66993 Hyaluronic acid sodium salt, Streptococcus equi, 91% 9067-32-7 500mg $40 2019-12-02 Buy
        Alfa Aesar J66993 Hyaluronic acid sodium salt, Streptococcus equi, 91% 9067-32-7 1g $60 2019-12-02 Buy
        Sigma-Aldrich H5388 Hyaluronic acid sodium salt from rooster comb avian glycosaminoglycan polysaccharide 9067-32-7 100mg $94.7 2019-12-02 Buy

        Sodium hyaluronate Chemical Properties,Uses,Production

        Physicochemical property

        Sodium hyaluronate is also called Hyaluronic acid sodium, is physiological active substances, which is widely exists in the human body. It is high molecular weignt straight-chain mucopolysaccharides, which is composed of glucuronic acid and acetyl amino hexose polymerizatio. its molecular weight is 1 million. In water, It can form a thick viscoelastic solution, has the physiological ph and ionic strength. The molecular configuration is variable, so also can be done with a fine needle. Sodium hyaluronate won't produce inflammatory substances , called Healon. The 10 mg dissolved in 1 ml saline solution, its thick viscosity is 200000 times higher than aqueous humor or saline water. Healon protein content is less than 0.5%, and a sterile solution with high purity.
        The structure of Sodium hyaluronate
        Figure 1 The structure of Sodium hyaluronate

        Sodium Hyaluronate Injection

        Hyaluronic acid sodium is a class of the non-drug neutral medium. Sodium hyaluronate injection is colorless transparent viscous liquid. Sodium hyaluronate is the main component of synovial joints , one of the components of cartilage matrix,and plays a role of lubrication in articular cavity, can reduce friction between organization, can play a role of the elastic at the same time and act the buffer effect of stress on articular cartilage, has their physiological function. High molecular weight, high concentration and high polymer viscoelasticity of sodium hyaluronate can significantly improve the joint inflammatory reaction, strengthen the function of joint fluid sticky and lubrication, protect the articular cartilage, promote the healing and regeneration of the articular cartilage, relieve pain, and increase the motion of Joint. The common dosage of sodium hyaluronate is: the jaw joints with 1 ml (10 mg), shoulder joint in 2 ml (20 mg), hip and knee with 2.5 ml (25 mg). It is mainly used in the treatment of degenerative osteoarthritis, traumatic arthritis, chronic rheumatic or rheumatoid arthritis, temporal jaw arthritis, femoral head aseptic necrosis.

        Application in Particular Diseases

        In Osteoarthritis:
        1. Four intraarticular hyaluronic acid preparations are available for treating pain associated with OA of the knee: sodium hyaluronate (Hyalgan 20 mg/2 mL; Supartz 25 mg/2.5 mL), hylan polymers (Synvisc 16 mg/2 mL), and hyaluronan (Orthovisc 30 mg/2 mL). Hyalgan and Supartz are administered once weekly for five injections, whereas Synvisc and Orthovisc are administered once weekly for three injections.
        2. Injections are well tolerated, but acute joint swelling and local skin reactions (e.g., rash, ecchymoses, or pruritus) have been reported.
        3. These products may be beneficial for OA of the knee that is unresponsive to other therapy, but they are expensive because treatment includes both drug and administration costs.

        Pharmacological action

        Sodium hyaluronate has the effect of promotinig wound healing. Sodium hyaluronate can form a macromolecular network barrier on the surface of eye tissue, preventing inflammatory content into the wound and lesion area, and can obviously increase the viscosity of liquids and adhesion, make the drug reserved and concentrated on the surface of the cornea for a long time, achieving long-term, powerful function. Sodium hyaluronate can stabilize tear film, prolong tear film broken, alleviate symptoms of dry eye. It is used for keratitis, corneal ulcer, the cornea injury caused by physical factors or other chemical burns.

        Pharmacodynamics

        (1)It can protect corneal endothelial in surgery, epithelium, iris and retina.
        (2)It can be instead of aqueous humor without loss, so it can keep the depth of anterior chamber during the surgery.
        (3)It is injected into glass cavity ,helping to reset the retina because of oppression.
        (4)It can enter the conjunctiva under the pillow to keep filter pillow uplift in glaucoma surgery.
        (5) It can help to reduce the adhesion for separation tissue surface.

        Pharmacokinetics

        Sodium hyaluronate is a component of the aqueous humor and vitreous body. When injected into anterior chamber or vitreous cavity, it can make a temporary increase in the concentration in every parts. In the anterior chamber, Healon gradually dilute by newborn aqueous humor and is discharged through the corner sclera sinus; Injected Healon into the vitreous cavity and again dilute aqueous humor then seep out . The monkey eyes experiment shows that Healon disappear entirely after 60~70 d in vitreous cavity. In the process, the concentration of Healon gradually weakened and its molecular remains the same. Healon injection into Monkey’s anterior chamber disappeared within 1 weeks. Clinical observation is similar to that of human eye.

        Clinical application

        Used in the surgeries such as intraocular lens, cataracts, glaucoma, corneal transplantation and retinal detachment .

        Usage dosage

        The injection is used commonly in anterior chamber, and each 0.5~0.5 ml.
        In Intraocular lens implant surgery, using Healon can keep up the entire operation process of the depth of anterior chamber, having wide position for the operation of cataract extraction and intraocular lens implantation, also can keep the shape and position of the tissue in anterior chamber to run the operation smoothly and reduce early post-operational complications. Healon which is in corneal transplant applicationcan, can protect the corneal endothelium from the tissue damage.

        Adverse reaction

        A minority of patients using Healon may be a transient (25~30 MMHG) elevated intraocular pressurewith after operation,then back to normal in 1~2 d. But at the end of the surgery injection balance the brine into anterior chamber to dilute Healon, did not have the phenomenon of elevated intraocular pressure.

        Precautions

        1.Topical (eye drop) can sometimes have a thrill, foreign body sensation, itching, reddening, diffuse surface keratitis, etc. After eye surgery, this drug with blood or residual crystals mixing in the eye , can delay absorption and inflammation, and short elevated intraocular pressure. Local injection can have a sexual pain swelling or fever. Possible allergies are: sometimes may be blepharitis, eyelid skin inflammation, individual patients can also be a skin rash, itching, rare shock, urticaria, etc.
        2. [contraindications]Allergies to this medicine , venous and lymphatic return leg disorders, patients with knee infection or inflammation, Articular cavity infection of acute phase to disable the articular cavity injection. To diabetic patients with no crystal, tis ban to the use of this drug in large quantities in surgery.
        3. Caution:Allergies to the drugs, liver dysfunction or a history of liver function obstacle, the elderly, children, pregnancy, nursing mothers.
        4. The use of this drug in the operation should be avoiding excessive packing. After the surgery with a balanced salt solution according to the need to remove residual liquid, this can control the intraocular pressure in case of elevated intraocular pressure.
        5. When used in osseous arthritis, It can be combined with prednisone dragon. This can relieve pain, and recover joint function.
        6. When it used in eye surgery, we should be closely monitoring intraoperative and postoperative intraocular pressure.
        About the information about the physical and chemical properties pharmacological action, pharmacokinetics, clinical application usage and dosage of sodium hyaluronate in ophthalmology by chemcialbook editor yaoyao(2015-09-24).

        Uses

        1.Used in dry eye syndrome.
        2.Widely used in high-end cosmetics industry, used in dry eye syndrome.

        Chemical Properties

        solid

        Chemical Properties

        The PhEur 6.3 describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic.

        Uses

        sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form.

        Uses

        Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.

        Uses

        antifungal agent

        Uses

        prevents thromboembolic complications

        Uses

        aldosterone antagonist used as an adjunct in the management of chronic heart failure

        Uses

        suitable as substrate for hyaluronidase

        Uses

        Surgical aid (ophthalmological).

        Definition

        Hyaluronic acid.

        Production Methods

        Sodium hyaluronate occurs naturally in vitreous humor, serum, chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs. It may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration. It is then precipitated with an organic solvent and dried.

        brand name

        Equron [Veterinary] (Fort Dodge Animal Health); Legend (Bayer Animal Health); Synacid [Veterinary] (Schering-Plough Animal Health).

        Pharmaceutical Applications

        Sodium hyaluronate is the predominant form of hyaluronic acid at physiological pH. The name hyaluronan is used when the polysaccharide is mentioned in general terms, and in the literature the terms hyaluronic acid and sodium hyaluronate are used interchangeably.
        Hyaluronan is used therapeutically to treat osteoarthritis in the knee, and is an effective treatment for arthritic pain. Crosslinked hyaluronan gels are used as drug delivery systems.
        Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.(4) This is useful for enhancing the availability and retention time of drugs administered to the eye. It is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery systems; it also has important applications in the fields of vascosurgery and vascosupplementation.

        Safety

        Sodium hyaluronate is used in cosmetics and in topical, parenteral, and ophthalmic pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material. Sodium hyaluronate has been reported to be an experimental teratogen.
        LD50 (mouse, IP): 1.5 g/kg
        LD50 (rabbit, IP): 1.82 g/kg
        LD50 (rat, IP): 1.77 g/kg

        storage

        Sodium hyaluronate should be stored in a cool, dry place in tightly sealed containers. The powder is stable for 3 years if stored in unopened containers.

        Regulatory Status

        Included in the FDA Inactive Ingredients Database (topical gel preparation).

        Sodium hyaluronate Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Sodium hyaluronate Suppliers

        Global( 318)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Nanjing Hanxin Pharmaceutical Technology Co., Ltd. 13770632542,13770347692;QQ:1135480185,3118159293
        025-52809826 sales@amphastar.cn China 20 58
        Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
        025-57019371 sales@sunlidabio.com China 3817 55
        ALB Technology Limited 702-983-3769
        702-983-3769 sales@albtechnology.com United States 2994 55
        BOC Sciences
        info@bocsci.com United States 10506 65
        Xi'an boliante Chemical Co., Ltd. 17719597442
        - 3570451756@qq.com China 2912 58
        Shaanxi billion Kang Long biological technology co., LTD 17791478691
        4009024560 997832940@qq.com China 286 58
        Hubei Jianwen Biomedical Co., Ltd. 18372107314
        027-87887055 2332576826@qq.com China 102 58
        Raw material medicin reagent co.,Ltd 025-57798860
        sales@njromanme.com China 4614 58
        A. V. T. (Shanghai) Pharmaceutical CO. Ltd. 021-58876118
        avt013@avt-cn.com China 54 58
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76

        View Lastest Price from Sodium hyaluronate manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2019-11-12 Sodium hyaluronate
        9067-32-7
        US $1.00 / KG 1KG 91% min 100MT Henan Xiangtong Chemical Co., Ltd.
        2019-04-02 Sodium hyaluronate Manufacturer; In stock GMP Factory
        9067-32-7
        US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
        2019-08-17 Sodium hyaluronate
        9067-32-7
        US $6.50 / KG 1KG 99.0% IN STOCK 800 MT per month Chemwill Asia Co.,Ltd.

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