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        4-Methylpyridine

        4-Methylpyridine
        4-Methylpyridine structure
        CAS No.
        108-89-4
        Chemical Name:
        4-Methylpyridine
        Synonyms
        GAMMAP;ba35846;4-PicoL;Ba 35846;g-picoline;p-Picoline;picoline-4;γ-Picoline;4-PICOLINE;GAMMA-PICOLINE
        CBNumber:
        CB3778430
        Molecular Formula:
        C6H7N
        Formula Weight:
        93.13
        MOL File:
        108-89-4.mol

        4-Methylpyridine Properties

        Melting point:
        2.4 °C(lit.)
        Boiling point:
        145 °C(lit.)
        Density 
        0.957 g/mL at 25 °C(lit.)
        vapor density 
        3.2 (vs air)
        vapor pressure 
        4 mm Hg ( 20 °C)
        refractive index 
        n20/D 1.504(lit.)
        Flash point:
        134 °F
        storage temp. 
        Flammables area
        solubility 
        alcohol: soluble(lit.)
        pka
        6.02(at 20℃)
        form 
        Liquid
        color 
        Clear light yellow
        Odor
        Obnoxious, Sweetish
        explosive limit
        1.3-8.7%(V)
        Water Solubility 
        soluble
        Sensitive 
        Air Sensitive & Hygroscopic
        Merck 
        14,7402
        BRN 
        104586
        InChIKey
        FKNQCJSGGFJEIZ-UHFFFAOYSA-N
        CAS DataBase Reference
        108-89-4(CAS DataBase Reference)
        EWG's Food Scores
        1-2
        NIST Chemistry Reference
        Pyridine, 4-methyl-(108-89-4)
        EPA Substance Registry System
        4-Methylpyridine (108-89-4)
        SAFETY
        • Risk and Safety Statements
        Symbol(GHS) 
        GHS02,GHS06
        Signal word  Danger
        Hazard statements  H226-H302-H311-H315-H319-H332-H335-H302+H332
        Precautionary statements  P261-P280-P305+P351+P338-P312-P210-P303+P361+P353-P405-P501a
        Hazard Codes  T
        Risk Statements  10-20/22-24-36/37/38
        Safety Statements  26-36-45
        RIDADR  UN 1992 3/PG 3
        WGK Germany  1
        RTECS  UT5425000
        Autoignition Temperature 1000 °F
        TSCA  Yes
        HazardClass  3
        PackingGroup  III
        HS Code  29333955
        Toxicity LD50 orally in rats: 1.29 g/kg (Smyth)
        NFPA 704
        2
        3 0

        4-Methylpyridine price More Price(12)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 131490 4-Methylpyridine 98% 108-89-4 25ml $28.1 2020-08-18 Buy
        Sigma-Aldrich 239615 4-Methylpyridine 99% 108-89-4 50ml $34.8 2020-08-18 Buy
        TCI Chemical P0417 4-Methylpyridine >98.0%(GC)(T) 108-89-4 25mL $14 2020-06-24 Buy
        TCI Chemical P0417 4-Methylpyridine >98.0%(GC)(T) 108-89-4 500mL $31 2020-06-24 Buy
        Alfa Aesar A15595 4-Picoline, 98% 108-89-4 500ml $32 2020-06-24 Buy

        4-Methylpyridine Chemical Properties,Uses,Production

        Chemical Properties

        Clear light yellow liquid

        Chemical Properties

        Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.

        Occurrence

        4-Methylpyridine is released by energy-related processes. It is present in coal gassification wastewater (Pellizzari et al 1979), the environment of coke ovens (Naizer and Mashek 1974) and in waters from shale oil waste production (Dobson et al 1985; Hawthorne et al 1985; Leenheer et al 1982). It is also present in coal tar (HSDB, 1988), cigarette smoke (Brunneman et al 1978; IARC 1976) and pyroligneous liquids from woods (Yasuhara and Sugiwara 1987). Methods for the biological treatment of wastewaters containing 4-methylpyridine have been developed (Roubickova 1986) and its movement through (Leenheer and Stuber 1981) and degradation (Sims and Somners 1985) in soils examined.

        Uses

        manufacture of isonicotinic acid and derivatives. In waterproofing agents for fabrics. As solvent for resins.

        Uses

        4-Methylpyridine is used to manufacture isonicotinic acid and derivatives, in waterproofing agents for fabric, and as a solvent for resins, pharmaceuticals, dyestuffs, rubber accelerators, and pesticides. It is also used as a catalyst and curing agent.

        Definition

        ChEBI: A methylpyridine in which the methyl substituent is at position 4.

        Production Methods

        Currently, 4-methylpyridine is produced by vapor-phase condensation of acetaldehyde and ammonia (3:1) with subsequent isolation of 4-methylpyridine from the reaction mixture. Reactants are exposed to dehydration-dehydrogenation catalysis such as lead oxide, copper oxide on alumina, thorium oxide, zinc oxide or cadmium oxide on silica-alumina, or cadmium fluoride on silica-magnesia at 400-500°C. This results in a 60% yield of 4-methylpyridine which is isolated by fractional distillation (USEPA 1982). Another production method involves the isolation from by-products of coking operations. The crude pyridine extracts come from noncondensable and condensable coke-oven gasses that have been dehydrated and separated by fractional distillation, but only 45% of 4-methylpyridine is obtained (USEPA 1982). 4-Methylpyridine also can be isolated from a dry distillation of bones or coal (Hawley 1977).

        General Description

        Colorless moderately volatile liquid.

        Air & Water Reactions

        Highly flammable.

        Reactivity Profile

        4-Methylpyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

        Health Hazard

        ACUTE/CHRONIC HAZARDS: Moderate fire risk.

        Health Hazard

        Data indicates that 4-methylpyridine is moderately toxic when administered orally and very toxic when given dermally and intraperitoneally (Smith 1982). Symptoms include occasional diarrhea, weight loss, anemia, and occular and facial paralysis.

        Fire Hazard

        HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

        Industrial uses

        4-Methylpyridine is used as a water-proofing agent for fabrics; as solvents for resins; in the synthesis of pharmaceuticals, dyestuffs, rubber accelerators, pesticides and laboratory reagent; as a catalyst; and as a curing agent (Hawley 1977; Windholz et al 1983). It is used for the synthesis of pharmaceuticals, especially isoniazid (USEPA 1982) and also for the production of 4-vinylpyridine to improve dyeability (USEPA 1982).

        Safety Profile

        Poison by ingestion and intraperitoneal routes. Moderately toxic by sktn contact. Mildly toxic by inhalation. A severe skin and eye irritant. Flammable liquid when exposed to heat, flames, oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

        Potential Exposure

        (o-isomer); Suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (m-isomer): Possible risk of forming tumors, Primary irritant (w/o allergic reaction). Picolines are used as intermediates in pharmaceutical manufacture, pesticide manufacture; and in the manufacture of dyes and rubber chemicals. It is also used as a solvent.

        Metabolism

        Pyridine and its alkyl derivatives are absorbed from the gastrointestinal tract, intraperitoneal cavity and lungs, with the peritoneal route being slightly more rapid and complete than gastrointestinal absorption. The methylpyridines also are rapidly absorbed through the skin (Reinhardt and BrittelH 1971).
        The addition of a methyl group onto the pyridine molecule increases the rate of absorption of the resultant methylpyridines into the liver, kidneys, and brains of rats (Zharikov et al 1983). It was found that 4-picoline has a shorter residence time than the other substituted picolines in the liver, brain and kidney. Elimination occurred via a biphasic process.
        Although the exact mechanism has not been determined, it appears that all methylpyridines are oxidized to their respective aromatic acids (Williams 1959). For example, the administration of 2-methylpyridine (0.5 to 1.0 g) to rabbits resulted in the excretion of unchanged parent compound along with α-picolinic acid.
        Formation of an N-oxide also occurs with 4-methylpyridine (Gorrod and Damani 1980).

        Shipping

        UN2313 Picolines, Hazard Class: 3; Labels: 3-Flammable liquid.

        Purification Methods

        It can be purified as for 2-methylpyridine. Biddescombe and Handley's method (above) for 3-methylpyridine is also applicable. Lidstone [J Chem Soc 242 1940] purified it via the oxalate (m 137-138o) by heating 100mL of 4-methylpyridine to 80o and adding slowly110g of anhydrous oxalic acid, followed by 150mL of boiling EtOH. After cooling and filtering, the precipitate is washed with a little EtOH, then recrystallised from EtOH, dissolved in the minimum quantity of water and distilled with excess 50% KOH. The distillate is dried with solid KOH and again distilled. Hydrocarbons can be removed from 4-methylpyridine by converting the latter to its hydrochloride, crystallising from EtOH/diethyl ether, regenerating the free base by adding alkali and distilling. As a final purification step, 4-methylpyridine can be fractionally crystallised by partial freezing to effect a separation from 3-methylpyridine. Contamination with 2,6-lutidine is detected by its strong absorption at 270nm. The hydrochloride has m 161o, and the picrate has m 167o(from Me2CO, EtOH or H2O). [Beilstein 20 III/IV 2732, 20/5 V 543.]

        Incompatibilities

        Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks copper and its alloys.

        4-Methylpyridine Preparation Products And Raw materials

        Raw materials

        Preparation Products


        4-Methylpyridine Suppliers

        Global( 256)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Mei Lan Industrial (Shanghai) Co., Ltd. 021-61500788
        021-58957967 wouchina@126.com China 2681 55
        Wuhan EnTai Technology Development Co,.Ltd 86-27-82330560
        86-27-82330547 2536851935@qq.com China 351 69
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96504 76
        Meryer (Shanghai) Chemical Technology Co., Ltd. 21-61259100-
        86-21-61259102 sh@meryer.com China 40268 62
        Alfa Aesar 400-610-6006; 021-67582000
        021-67582001/03/05 saleschina@alfa-asia.com China 30163 84
        TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
        021-67121385 Sales-CN@TCIchemicals.com China 24555 81
        Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820
        86 (10) 60270825 dtftchem@sina.com China 3393 62
        Energy Chemical 021-58432009
        021-58436166-800 sales8178@energy-chemical.com China 44026 61
        Beijing Ouhe Technology Co., Ltd 010-82967028-
        +86-10-82967029 2355560935@qq.com China 12365 60
        JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
        86-021-50426522,50426273 sales@jingyan-chemical.com China 10009 60

        View Lastest Price from 4-Methylpyridine manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2018-08-09 4-Methylpyridine
        108-89-4
        US $2.00 / KG 1KG 99% Customise career henan chemical co

        4-Methylpyridine Spectrum


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