老彩票app下载

<address id="gUwjA"></address><datalist id="gUwjA"><strike id="gUwjA"></strike></datalist>
    <param id="gUwjA"><progress id="gUwjA"><figcaption id="gUwjA"></figcaption></progress></param>

    <figcaption id="gUwjA"><section id="gUwjA"><area id="gUwjA"><address id="gUwjA"></address><i id="gUwjA"></i><nav id="gUwjA"></nav></area><rp id="gUwjA"></rp><bdo id="gUwjA"><dl id="gUwjA"><sub id="gUwjA"></sub></dl></bdo></section><figcaption id="gUwjA"></figcaption></figcaption>

      • <bdo id="gUwjA"></bdo><span id="gUwjA"><td id="gUwjA"></td></span><rp id="gUwjA"></rp>
        ChemicalBook
        Chinese Japanese Germany Korea

        Guanine

        Organic bases 6-Thioguanine Chemical Properties Uses Production method
        Guanine
        Guanine structure
        CAS No.
        73-40-5
        Chemical Name:
        Guanine
        Synonyms
        Gua;Guanie;uanine;Guanin;GUANINE;ci75170;guamine;quanine;dewpearl;Dew Pearl
        CBNumber:
        CB3259805
        Molecular Formula:
        C5H5N5O
        Formula Weight:
        151.13
        MOL File:
        73-40-5.mol

        Guanine Properties

        Melting point:
        >300 °C(lit.)
        Boiling point:
        273.11°C (rough estimate)
        Density 
        1.4456 (rough estimate)
        refractive index 
        2.0000 (estimate)
        storage temp. 
        2-8°C
        solubility 
        1 M NaOH: 0.1 M at 20 °C, clear, colorless
        form 
        Powder
        pka
        9.92(at 40℃)
        color 
        White to cream
        Odor
        Odorless
        Water Solubility 
        practically insoluble
        Decomposition 
        360°C
        Merck 
        14,4564
        BRN 
        9680
        Stability:
        Stable. Incompatible with strong oxidizing agents.
        InChIKey
        UYTPUPDQBNUYGX-UHFFFAOYSA-N
        CAS DataBase Reference
        73-40-5(CAS DataBase Reference)
        FDA 21 CFR
        73.1329; 73.2329
        EWG's Food Scores
        1
        FDA UNII
        5Z93L87A1R
        NIST Chemistry Reference
        6H-Purin-6-one, 2-amino-1,7-dihydro-(73-40-5)
        EPA Substance Registry System
        Guanine (73-40-5)
        SAFETY
        • Risk and Safety Statements
        Symbol(GHS) 
        GHS07
        Signal word  Warning
        Hazard statements  H315-H319-H335
        Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
        Hazard Codes  Xi
        Risk Statements  36/37/38
        Safety Statements  26-36-37/39
        WGK Germany  3
        RTECS  MF8260000
        Hazard Note  Irritant
        TSCA  Yes
        HS Code  29335990
        NFPA 704
        1
        1 0

        Guanine price More Price(13)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich G11950 Guanine 98% 73-40-5 10g $22.9 2019-12-02 Buy
        Sigma-Aldrich 1302156 Guanine United States Pharmacopeia (USP) Reference Standard 73-40-5 100mg $392 2019-12-02 Buy
        TCI Chemical G0169 Guanine >98.0%(T)(HPLC) 73-40-5 1g $14 2019-12-02 Buy
        TCI Chemical G0169 Guanine >98.0%(T)(HPLC) 73-40-5 25g $32 2019-12-02 Buy
        Alfa Aesar A12024 Guanine, 98% 73-40-5 100g $64.2 2019-12-02 Buy

        Guanine Chemical Properties,Uses,Production

        Organic bases

        Guanine is an organic base that is widespread in the animal and the plant kingdom. The chemical name is 2-amino-6-oxo-purin. It is colorless square crystals or crystalline powder. In the aqueous solution containing a large excess of ammonia, it will become small diamond crystal after slowly evaporating the water. It has a melting point of 360 ℃ (partially decomposed and sublimated). It can be dissolved in ammonia water, caustic soda and dilute mineral acid, slightly soluble in ethanol, ethyl ether, and insoluble in water. It has a strong UV absorption. It is the major composition of guanosine and guanylate. Its hydrochloride monohydrate is powdery crystals with water being loss at 100 ℃ and hydrogen chloride being loss at 200 ℃. It can be dissolved in acidified water but is insoluble in water, alcohol, and ether. Guanine can be obtained through the hydrolysis of scale in hydrochloric acid. It is an important base composition of nucleic acids, being one of the four major bases of DNA and RNA as well as the compassion of various kinds of guanylate. Its N9 can be connected with the C1 of ribose or deoxyribose with β-glycosidic bond to obtain guanosine or deoxy-guanosine.
        [Major application]: for biochemical research and preparation of caffeine and other drugs.
        Its chemical composition is 2-amino-6-mercaptopurine. It, together with adenine, constitutes the two major purines bases in the nucleic acid. Through binding to ribose guanosine or deoxyribose guanosine through the glycosidic linkages, the corresponding triphosphates are guanosine triphosphate or deoxyguanosine triphosphate, respectively. They are the precursor of guanine during the biosynthesis process of RNA and DNA.

        6-Thioguanine

        6-Thioguanine belongs to another kind of common purine metabolism antagonist in the inhibition of the purine synthesis pathway and is a cell cycle specific drugs to which those cells locating in the cycle S period are most sensitive. In addition to inhibit the biosynthesis of cellular DNA, it also has mild inhibitory effect on the biosynthesis of RNA. This product is a kind of guanosine analogs. It becomes active only after being converted to 6-TG ribonucleotide via the phosphor-ribosyltransferase inside human body. The action process of this product is similar to that of mercapto-purine. In addition, 6-TG ribonucleotide, through its inhibitory effect on guanylate kinase, can prevent the phosphorylation of guanosine monophosphate (GMP) into guanosine diphosphate (GDP). This product, after being metabolized into deoxyribonucleoside triphosphate, can be embedded in DNA, thus further inhibiting the biosynthesis of nucleic acids while mercaptopurine having no effect. The product has cross-resistance with mercaptopurine while it can have its efficacy improved upon combination with other drugs such as cytarabine. Its oral absorption after oral administration is incomplete, at about 30%. Only a relatively small amount of the drug can shift from the blood to penetrate through the blood-brain barrier, therefore at generally oral dose, it is insufficient to prevent and treat meningeal leukemia. The activation and decomposition process of the product both proceeds in the liver with being de-activated through either shifting the amino-methyl mercaptopurine via methylation or shifting to mercaptopurine via deamination. However, the metabolic process of inactivation is not related to xanthine oxidase, therefore taking allopurinol has no significant inhibitory effect on the metabolism of this product. The half-life of intravenous injection is 25~240 min with the average period being 80 min. Through being excreted through the kidneys, for one time of oral administration, about 40% of the drug is excreted in urine in the form of metabolites within 24h with only trace amount of 6-Thioguanine being detected in the urine.

        Chemical Properties

        It is colorless needle crystal or amorphous powder. The melting point is 360 ℃ (decomposition). It is easily soluble in acid and alkali, slightly soluble in alcohol, ether, but insoluble in water.
        The above information is edited by the chemicalbook of Dai Xiongfeng.

        Uses

        It can be used for biochemical studies.
        It can be used as the intermediates of the antiviral drugs acyclovir.
        It can be used as the intermediate of thioguanine and open-ringed guanine.

        Production method

        5-amino-4-imidazolyl amide can have esterification reaction with isothiocyanate methylbenzene to generate ester, and then successfully reacted with methyl iodide, ammonia to synthesize it.

        Chemical Properties

        white to light yellow crystal powder

        History

        Guanine is one of the two purines comprising the five nucleic acid bases. Much of the information regarding the general role of nucleic acid bases is covered in Adenine and Cytosine. Guanine gets its name from guano, from which it was first isolated in the 1840s. Albrecht Kossel (1853 1927) determined that guanine (as well as adenine, cytosine, thymine and uracil) was a component of nucleic acid in the last two decades of the 19th century. Similar to adenine, guanine combines with ribose to form a nucleoside. The nucleoside produced is guanosine, which in turn combines with one to three phosphoryls to yield the nucleotides guanosine monophosphate (GMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP), respectively. Guanine nucleotides play an important role in metabolism including the conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) and carbohydrate metabolism.

        Uses

        Guanine is a crystalline amorphous substance that is found in guano, fish scales, and theliver of certain mammals. Guanine is responsible for the silvery iridescence of certain fishscales. Before its discovery, guanine was scraped from fish scales and used to coat beads to produceimitation pearls. Thus it was called pearl essence or pearly white in the 1700s. Guanineobtained from fish scales is used in cosmetics, especially for eye cosmetics and nail polishes.

        Uses

        Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.

        Uses

        guanine is mixed in water and used primarily in nail polish to achieve a pearlized effect. It has been greatly replaced by either synthetic pearl or aluminum and bronze particles. guanine is obtained from plant or animal sources.

        Definition

        A nitrogenous base found in DNA and RNA. Guanine has a purine ring structure.

        Definition

        guanine: A purine derivative. It isone of the major component bases ofnucleotides and the nucleic acidsDNA and RNA.

        Definition

        ChEBI: A 2-aminopurine carrying a 6-oxo substituent.

        Guanine Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Guanine Suppliers

        Global( 459)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Shanghai JONLN Reagent Co., Ltd. 400-0066400;021-60496031
        021-55660885 422131432@qq.com;422131432@qq.com China 9999 55
        Nanjing Jinhao Pharmaceutical Co., Ltd. 13382796873;13376086365;15851804510
        025-58602884 hjz8008@163.com China 47 58
        Changzhou Qiyu Biotechnology Co., Ltd.
        zzyqqq@163.com China 64 58
        Wuhan yuqing jiaheng pharmaceutical co. LTD 027-83855381-
        027-83855381 xiaozhan0503@163.com; China 944 58
        Shenzhen Kaimingke Biotechnology Co., Ltd. 181-26439142-
        1144496688@QQ.COM; China 171 58
        Wuxi Jingyao Bio-Technology Co., Ltd. 510-88770633-
        jingyaobiotech@126.com; China 264 55
        Watson Biotechnology Co.,Ltd 027-59207879-
        QQ:1972026995 kf@3600chem.com China 4133 55
        Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
        +86-21-57758967 sales@boylechem.com China 2214 55
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
        Meryer (Shanghai) Chemical Technology Co., Ltd. 21-61259100-
        86-21-61259102 sh@meryer.com China 40268 62

        View Lastest Price from Guanine manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2020-05-27 Guanine
        73-40-5
        US $0.00 / mg 100mg ≥98%(HPLC) 100 g Shanghai Standard Technology Co., Ltd.
        2019-07-12 Guanine
        73-40-5
        US $1.00 / Kg/Drum 1KG 99% 99999tons Shandong Kangmailin Chemical Technology Co. Ltd..
        2018-08-07 Guanine
        73-40-5
        US $1.00 / KG 1KG 98% 20KG career henan chemical co

        Guanine Spectrum


        73-40-5(Guanine)Related Search:


        Copyright 2017 © ChemicalBook. All rights reserved
        <address id="gUwjA"></address><datalist id="gUwjA"><strike id="gUwjA"></strike></datalist>
        <param id="gUwjA"><progress id="gUwjA"><figcaption id="gUwjA"></figcaption></progress></param>

        <figcaption id="gUwjA"><section id="gUwjA"><area id="gUwjA"><address id="gUwjA"></address><i id="gUwjA"></i><nav id="gUwjA"></nav></area><rp id="gUwjA"></rp><bdo id="gUwjA"><dl id="gUwjA"><sub id="gUwjA"></sub></dl></bdo></section><figcaption id="gUwjA"></figcaption></figcaption>

          • <bdo id="gUwjA"></bdo><span id="gUwjA"><td id="gUwjA"></td></span><rp id="gUwjA"></rp>