老彩票app下载

<address id="gUwjA"></address><datalist id="gUwjA"><strike id="gUwjA"></strike></datalist>
    <param id="gUwjA"><progress id="gUwjA"><figcaption id="gUwjA"></figcaption></progress></param>

    <figcaption id="gUwjA"><section id="gUwjA"><area id="gUwjA"><address id="gUwjA"></address><i id="gUwjA"></i><nav id="gUwjA"></nav></area><rp id="gUwjA"></rp><bdo id="gUwjA"><dl id="gUwjA"><sub id="gUwjA"></sub></dl></bdo></section><figcaption id="gUwjA"></figcaption></figcaption>

      • <bdo id="gUwjA"></bdo><span id="gUwjA"><td id="gUwjA"></td></span><rp id="gUwjA"></rp>
        ChemicalBook
        Chinese Japanese Germany Korea

        Chlorogenic acid

        Pharmacological action Protecting liver, gallbladder The inhibitory effect on hyaluronidase and glucose - 6 - phosphatase The character of molecular structure Preparation method HPLC method for determination the content Toxicity Chemical property Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage and transport properties Fire extinguishing agent
        Chlorogenic acid
        Chlorogenic acid structure
        CAS No.
        327-97-9
        Chemical Name:
        Chlorogenic acid
        Synonyms
        Scorpio。;Heriguard;NSC 70861;Buthotoxin;NSC 407296;Chlorogenic;Igasuric acid;Chlorogenic ac;HELIANTHIC ACID;CHLOROGENID ACID
        CBNumber:
        CB2478906
        Molecular Formula:
        C16H18O9
        Formula Weight:
        354.31
        MOL File:
        327-97-9.mol

        Chlorogenic acid Properties

        Melting point:
        210 °C (dec.)(lit.)
        alpha 
        -36 º (c=1, H2O)
        Boiling point:
        407.55°C (rough estimate)
        Density 
        1.3594 (rough estimate)
        refractive index 
        -37 ° (C=1, H2O)
        storage temp. 
        0-6°C
        solubility 
        Soluble in ethanol and acetone.
        pka
        3.91±0.50(Predicted)
        form 
        Powder, Crystals, Needles and/or Chunks
        color 
        White to almost white
        Water Solubility 
        SOLUBLE IN HOT WATER
        Merck 
        14,2142
        InChIKey
        CWVRJTMFETXNAD-JUHZACGLSA-N
        CAS DataBase Reference
        327-97-9(CAS DataBase Reference)
        EPA Substance Registry System
        Chlorogenic acid (327-97-9)
        SAFETY
        • Risk and Safety Statements
        Hazard Codes  Xi
        Risk Statements  68
        Safety Statements  24/25
        WGK Germany  3
        RTECS  GU8480000
        Hazard Note  Irritant
        HS Code  29182900
        Toxicity LDLo intraperitoneal in rat: 4gm/kg

        Chlorogenic acid price More Price(16)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 1115545 Chlorogenic acid United States Pharmacopeia (USP) Reference Standard 327-97-9 50mg $313.6 2019-12-02 Buy
        Sigma-Aldrich 00500590 Chlorogenic acid primary reference standard 327-97-9 25mg $376 2019-12-02 Buy
        TCI Chemical C0181 Chlorogenic Acid Hydrate >98.0%(HPLC)(T) 327-97-9 1g $75 2019-12-02 Buy
        TCI Chemical C0181 Chlorogenic Acid Hydrate >98.0%(HPLC)(T) 327-97-9 5g $264 2019-12-02 Buy
        Alfa Aesar J60457 Chlorogenic acid 327-97-9 5g $283 2019-12-02 Buy

        Chlorogenic acid Chemical Properties,Uses,Production

        Pharmacological action

        Chlorogenic acid is also called "green" auspicious acid, tannins "coffee", "coffee tannic acid", is a plant produce a styrene acrylic compounds through shikimic acid hitches in aerobic respiration process.It is coffee acyl quinic acid derivatives.The oxidation resistance is strong, and also has the anti HIV, anti tumor cells, antibacterial, improve central excited, cholagogue function.It has teratogenic, allergy and regulate the activity of cytochrome P450 ligase, and other functions.It is widely exist in more content honeysuckle plants. It is obtained by the water needle crystal, and it is the hemihydrate, when 110 ℃ it is to hydrate. Melting point is 208 ℃, [a] D25 33.5 ° (water, C = 1), K = 2.2 x 10-3 (27 ℃).It is weak acidity and convergence. When 25 ℃ , the solubility in water is 4%, easily soluble in hot water, but soluble in ethanol, acetone, slightly soluble in ethyl acetate, insoluble in chloroform, ether and carbon disulfide. It is azeotropic with concentrated hydrochloric acid and come to blue dye. It can make the bromine water fade, It is azeotropic with strong hydrogen iodide and obtain benzoic acid, It is obtained phenol by thermal decomposition together with water at 230 ℃, It decomposite to caffeic acid and quinic acid with dilute hydrochloric acid, and caffeic acid and quinic acid with dilute alkali at room temperature. Chlorogenic acid and its isomer different chlorogenic acid and green chlorogenic acid are in fruits of dicotyledonous plants, leaves, and other organizations,which is an important factor for plant metabolism. Chlorogenic acid has good biological activity, the transparent acid enzyme and inhibition of glucose-6-phosphatase, free radical lipid perxidation qing mutagenesis resistance and cardiovascular crown reinforcement, special efficacy in lipid-lowering, both anti-bacterial anti-virus, protecting liver cholagogic.
        Chlorogenic acid as the condensation product of caffeic acid and quinic acid, is blue when meeting with iron, which is similar to tannins , but not precipitated with protein, so no convergence. Caffeic acid and chlorogenic acid has the wide bacteriostasis, but can be inactivated protein in the body. This product is similar to caffeine, oral or intraperitoneal injection, can improve the rat central excitability. Oral the drug of chlorogenic acid and coffee acid can increase the amount of hydrochloric acid secretion in the stomach, and can make slow pulse, and quinic acid is not. Chlorogenic acid could significantly increase small intestine peristalsis on the rat or mouse. Chlorogenic acid, caffeic acid and quinic acid can increase the tension of rat uterus, this function can be cancelled by papaverine, while atropine can't influence. Caffeic acid, chlorogenic acid, also can promote bile secretion in rats. On the specimens of rabbit ileum in vitro, this product can enhance the effect of adrenaline, but has no effect on blood glucose of adrenaline.

        Protecting liver, gallbladder

        Chlorogenic acid in flos lonicerae has favorable gallbladder function, promoting biliary Secretion of rats. Injection of 200 mg/kg chlorogenic acid to browns MAO honeysuckle total saponins subcutaneous can be significantly against CCl4, paracetamol and the increase of serum GPT caused by galactosamine in mice liver and liver triglyceride levels, and significantly reduce the severity of the liver pathological damage, making dot necrosis number sum and necrosis occur rate liver decreased obviously.

        The inhibitory effect on hyaluronidase and glucose - 6 - phosphatase

        Hyaluronic cranberry (HAase) is one of the cracking mucopolysaccharide enzymes, can catalyze hyaluronic acid (HA) decomposition,which is in relation to the permeability of vascular system and inflammation. HA is a mucopolysaccharide, which is composed of uronic acid and acetyl glucosamine, having a variety of functions, such as heal, make the skin wetting health, lubricating joints and prevent inflammation, etc. 3, 5-2 coffee acyl quinic acid (artichoke acid) and chlorogenic acid found in the ethyl acetate extract from the narrow assists cone flower (Echinacea amgustifolia DC) roots have stronger inhibitory effect of HAase activated. Animal in vitro studies have demonstrated that chlorogenic acid can not reversible inhibition of glucose-6-hydrolysis of phosphatase, reduce liver glycogen decomposition and exogenous glucose absorption. Animal studies have shown that the use of chlorogenic acid can reduce high blood sugar spikes caused by the use of glucagon (glycogenolysis). Therefore, chlorogenic acid can lower blood sugar level, improve the liver glucose-6-phosphoric acid and the concentration of hepatic glycogen.

        The character of molecular structure

        Chlorogenic acid is formed by caffeic acid and quinic acid, and the molecular structure has ester bond, unsaturated double bond and polyphenol unstable part of the three. In the process of extracted from plants, chlorogenic acid often happen by hydrolysis and intramolecular ester base migration isomerization . Due to the special structure of chlorogenic acid, it can extract from plants by the polarity solvent such as ethanol, acetone, methanol. But due to the instability of chlorogenic acid itself, extraction can not be in high temperature, strong light and heat for a long time. Chlorogenic acid liquid were placed in brown bottle, refrigerator (2 ℃) to save to be the most stable.

        Preparation method

        It can be obtained by (1S)-1-ethoxyformyloxy-3-cis-[3,4-dihydroxy-anti-cinnamoyl oxygen radicals]-4'-anti-5'-anti-dihydroxy cyclohexane-γ-methyl formate with barium hydroxide in methanol catalytic hydrolysis, or by the segregation from green coffee beans.

        HPLC method for determination the content

        (1)Chromatographic conditions: octadecyl silane bonded silica gel as the filling agent; Acetonitrile-0.4% phosphoric acid solution (13:87) as mobile phase; Detection wavelength of 327 nm. Theoretical plate number according to the chromatographic peak of chlorogenic acid is greater than 1000. (2)the preparation of the reference substance solution: precisely weigh the right amount of chlorogenic acid reference substance, placed in brown volumetric flask, adding 50% methanol solution containing 40 μg /mL (saving below 10 ℃). (3)the preparation of sample solution: taking samples of dry powder is about 0.5 g, precision said, with a plug in the conical flask, adding 50 ml 50% methanol , 30 min ultrasonic processing , cooling, weighing, make up the weight loss reduction with 50% methanol, shake well, filtration, abandoned the early filtrate, precision measuring duration of filtrate 5 ml, 25 ml volumetric brown flask , add 50% methanol to the scale, shake well. (4)assimilate precision respectively from each 10 μL reference substance and the sample solution, injection liquid chromatograph, determination,obtained.

        Toxicity

        Chlorogenic acid is sensitive to people, can cause asthma, dermatitis, but no this reaction to the oral of chlorogenic acid. It can be active no sensitization substances by small intestinal secretions convertion to. The toxicity of chlorogenic acid is very small, LD50 is greater than 1 g/kg to young rats, intraperitoneal injection of greater than 0.25 g/kg.

        Chemical property

        Hemihydrate is needle crystal (water). When 110 ℃, it become to anhydrous compounds. Melting point: 208 ℃, [alpha] 20D-35.2 (C = 2.8). When 25 ℃, water solubility was 4%, solubility is bigger in the hot water. Soluble in ethanol and acetone, slightly soluble in ethyl acetate.

        Uses

        It has broad antibacterial effect, advantageous bravery, hemostatic, increase white blood cell and antiviral effect, the effect of the blood clotting and bleeding time is shortened. It is used in the treatment of upper respiratory tract infection, anti-inflammatory and antipyretic, cool blood heat dissipation. Used as pharmaceutical raw materials and intermediates. clearing heat and removing toxicity, cold wind heat, broad-spectrum antimicrobial properties, having obvious inhibitory effect to hemolytic streptococcus, dysentery rod gas and salmonella typhi bacteria

        Category

        Toxic substances

        Toxicity grading

        toxication

        Acute toxicity

        Abdominal cavity-rat LDL0:4000 mg/kg

        Flammability hazard characteristics

        Combustible; Release acrid smoke fire

        Storage and transport properties

        Low temperature warehouse, ventilated, dry

        Fire extinguishing agent

        Water, carbon dioxide, dry powder, sand

        Chemical Properties

        white to slightly yellowish-beige powder

        Uses

        antioxidant, free radical scavenger

        Uses

        A major component of green coffee the extracts of which promote weight loss in overweight and obese people. Chlorogenic Acid is an important intermediate in lignin biosynthesis. Chlorogenic Acid is an antioxidant and an inhibitor of the tumor promoting activity of phorbol ester. It has protective effect against streptozotocin-nicotinamide generated oxidative stress induced diabetes and may also pr otect against cardiovascular disease.

        Purification Methods

        Crystallise the acid from water and dry it at 110o. [Beilstein 10 H 537, 10 I 271, 10 II 378, 10 III 2408, 10 IV 2259.]

        Chlorogenic acid Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Chlorogenic acid Suppliers

        Global( 427)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Puripharm Co., Ltd. 0572-2745768-1;0572-2717806-
        13167223168 sales@puripharm.com;yzm@puripharm.com China 219 65
        Microherb Inc. +86 (744) 832-8128
        QQ:2236179442; Skype:donviez sales@microherb.cn China 48 50
        Kono Chem Co.,Ltd 029-86107037-8012
        029-86107037 info@konochemical.com China 2366 55
        Shandong XiYa Chemical Industry Co., Ltd
        0539-6365991 3229735657@qq.com China 26779 60
        Shanghai ChengShao Biological Technology Co., Ltd. 021-61847300 13341622919
        021-61847300 shcss01@163.com China 4810 58
        Shanghai Orgchem Co.,Ltd. +86-21-5877 1921
        +86-21-5877 1925 info@chemofchina.com China 9692 55
        Changsha Staherb Natural Ingredients Co., Ltd. 0731-84213302- ;0731-84213302-
        0731-85953715 sales18@staherb.cn;sales12@staherb.cn China 266 58
        Shaanxi Pioneer Biotech Co., Ltd. 15691860074; 029-84385017-8009
        029-84385017 sales@pioneerbiotech.com China 2113 56
        JIURUI BIOLOGY & CHEMISTRY CO.,LTD. 86-744-8561910/18507445225
        86-744-8561910 info@jiuruibiochem.com/sales@jiuruibiochem.com/sales13@jiuruibiochem.com China 16 55
        Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
        +86-21-57758967 sales@boylechem.com China 2214 55

        View Lastest Price from Chlorogenic acid manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2019-10-11 Chlorogenic acid
        327-97-9
        US $0.00 / mg 5mg Analytical Standard 10 g Shanghai Standard Technology Co., Ltd.
        2019-10-11 Chlorogenic acid
        327-97-9
        US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
        2019-07-15 Chlorogenic acid 327-97-9
        327-97-9
        US $38.50 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

        Chlorogenic acid Spectrum


        327-97-9(Chlorogenic acid)Related Search:


        Copyright 2017 © ChemicalBook. All rights reserved
        <address id="gUwjA"></address><datalist id="gUwjA"><strike id="gUwjA"></strike></datalist>
        <param id="gUwjA"><progress id="gUwjA"><figcaption id="gUwjA"></figcaption></progress></param>

        <figcaption id="gUwjA"><section id="gUwjA"><area id="gUwjA"><address id="gUwjA"></address><i id="gUwjA"></i><nav id="gUwjA"></nav></area><rp id="gUwjA"></rp><bdo id="gUwjA"><dl id="gUwjA"><sub id="gUwjA"></sub></dl></bdo></section><figcaption id="gUwjA"></figcaption></figcaption>

          • <bdo id="gUwjA"></bdo><span id="gUwjA"><td id="gUwjA"></td></span><rp id="gUwjA"></rp>