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        Dihydrotachysterol

        Description Pharmacodynamics Indication Uses References
        Dihydrotachysterol
        Dihydrotachysterol structure
        CAS No.
        67-96-9
        Chemical Name:
        Dihydrotachysterol
        Synonyms
        dht2;AT-10;C06957;Dygrayl;dihydral;dygratyl;parterol;Tachyrol;ANTITANIL;CALCAMINE
        CBNumber:
        CB2469405
        Molecular Formula:
        C28H46O
        Formula Weight:
        398.66
        MOL File:
        67-96-9.mol

        Dihydrotachysterol Properties

        Melting point:
        116-120°C
        alpha 
        D22 +97.5° (chloroform)
        Boiling point:
        461.8°C (rough estimate)
        Density 
        0.9678 (rough estimate)
        refractive index 
        1.5100 (estimate)
        storage temp. 
        2-8°C
        solubility 
        Practically insoluble in water, freely soluble in acetone and hexane, sparingly soluble in ethanol (96 per cent).
        pka
        14.96±0.40(Predicted)
        form 
        neat
        InChIKey
        ILYCWAKSDCYMBB-KWOSLRGBSA-N
        SAFETY
        • Risk and Safety Statements
        Symbol(GHS) 
        GHS06
        Signal word  Danger
        Hazard statements  H301
        Precautionary statements  P301+P310
        Hazard Codes  Xn
        Risk Statements  22
        Safety Statements  36
        RIDADR  UN 2811 6.1/PG 3
        WGK Germany  3
        RTECS  WW0600000
        HazardClass  6.1(b)
        PackingGroup  III
        HS Code  2936299055
        Toxicity LD50 oral in mouse: 288mg/kg

        Dihydrotachysterol price More Price(4)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich D9257 Dihydrotachysterol analytical standard 67-96-9 50mg $155 2019-12-02 Buy
        Sigma-Aldrich 1204000 Dihydrotachysterol United States Pharmacopeia (USP) Reference Standard 67-96-9 4x30mg $338.1 2019-12-02 Buy
        Sigma-Aldrich Y0000482 Dihydrotachysterol for system suitability European Pharmacopoeia (EP) Reference Standard 67-96-9 y0000482 $183 2019-12-02 Buy
        Sigma-Aldrich Y0000544 Dihydrotachysterol European Pharmacopoeia (EP) Reference Standard 67-96-9 y0000544 $183 2019-12-02 Buy

        Dihydrotachysterol Chemical Properties,Uses,Production

        Description

        Dihydrotachysterol is a synthetic analog of vitamin D. It is considered as a reduction product of vitamin D2 (ergocalciferol). It stimulates bone mineralization as well as calcium and phosphorus absorption in intestine. Dihydrotachysterol has been used for the treatment of hypoparathyroidism, osteomalacia, osteoporosis, low calcium level, and kidney osteodystrophy. Though dihydrotachysterol is more expensive, dihydrotychysterol therapy is preferred as it has a more rapid onset of action (1-7 d) and a shorter time for dissipation of effect in the event of toxicity (2-3 weeks) than vitamin D2.

        Pharmacodynamics

        Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1,25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. It also increases renal phosphate excretion. In contrast to parathyroid extract, dihydrotachysterol is active when taken orally, exerts a slow but persistent effect, and may be used for long periods without increasing the dosage or causing tolerance. Dihydrotachysterol is faster-acting than pharmacologic doses of vitamin D and is less persistent after cessation of treatment, thus decreasing the risk of accumulation and of hypercalcemia.

        Indication

        Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).

        Uses

        1. Dihydrotachysterol is a form of vitamin D. Vitamin D is a fat-soluble vitamin and has properties of both vitamins and minerals. Vitamin D helps you to absorb calcium from what you eat. You need calcium to keep your bones strong, and to help your muscles and nerves work properly.
        2. The term Vitamin D collectively refers to a group of structurally similar chemicals and their metabolites, which includes alfacalcidol (1 α hydroxycholecalciferol), calcitriol (1,25-dihydroxychole-calciferol), cholecalciferol (Vitamin D3), dihydrotachysterol(DHT) and ergocalciferol (Vitamin D2). These agents have antirachitic properties.
        3. Dihydrotachysterol-2 (DHT-2) is a vitamin D2 analog for the Pharmaceutical industry.
        4. Dihydrotachysterol-2 is used in the prevention and treatment of several bone growth disorders such as osteoporosis. Besides this the substance is also used to treat several abnormalities of the parathyroid glands such as hypoprathyroidism.

        References

        1. https://en.wikipedia.org/wiki/Dihydrotachysterol
        2. https://www.drugbank.ca/drugs/DB01070
        3. https://pubchem.ncbi.nlm.nih.gov
        4. Jack Z. Yetiv and Joseph R. Bianchine, Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders, 1981, ISBN 0-12-788950-7
        5. Carl P. Weiner and Kate Rope, The Complete Guide to Medications During Pregnancy and Breastfeeding, 2013, ISBN-10: 0312676468

        Chemical Properties

        White Solid

        Uses

        Calcium regulator. Preparation by reduction of Tachysterol. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids.

        Definition

        ChEBI: A hydroxy seco-steroid that is 9,10-secoergosta-5,7,22-triene substituted by a hydroxy group at position 3. A synthetic analogue of vitamin D that acts a bone density conservation agent.

        brand name

        Hytakerol (Sterling Winthrop).

        Veterinary Drugs and Treatments

        DHT is used in small animals to treat hypocalcemia secondary to hypoparathyroidism or severe renal disease.

        Purification Methods

        Crystallise the sterol from 90% MeOH, UV: max at 242, 251 and 261nm (E1% 760, 1010 and 650) in EtOH. The acetate has m108-110o and [] +32.8o (CHCl3), UV: max at 242, 251 and 261nm (E 780, 910 and 600) in EtOH. The propionate has m 97-98o and [] +37o (CHCl3), UV: max 242, 251 and 261nm (E 750, 860 and 570) in EtOH. [Werder Hoppe Seyler's Z Physiol Chem 260 119 1939, Windaus et al. Justus Liebigs Ann Chem 499 1978 1932, Beilstein 6 III 2833, 6 IV 3994, 4161.]

        Dihydrotachysterol Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Dihydrotachysterol Suppliers

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