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        description Chemical Properties side effects Uses Synthesis
        Phenothiazine structure
        CAS No.
        Chemical Name:
        XL-50;ent38;Feeno;Biverm;ENT 38;Orimon;Reconox;PHENOXUR;VERMITIN;Agrazine
        Molecular Formula:
        Formula Weight:
        MOL File:

        Phenothiazine Properties

        Melting point:
        184 °C
        Boiling point:
        371 °C(lit.)
        vapor pressure 
        0.0000647 Pa (20 °C)
        refractive index 
        Flash point:
        storage temp. 
        Store below +30°C.
        pKa 2.52 (Uncertain)
        Prills or Beads
        6 (10g/l, H2O, 20℃)(aqueous suspension)
        Water Solubility 
        2 mg/L (25 ºC)
        Light Sensitive
        Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
        CAS DataBase Reference
        92-84-2(CAS DataBase Reference)
        NIST Chemistry Reference
        EPA Substance Registry System
        Phenothiazine (92-84-2)
        • Risk and Safety Statements
        Signal word  Warning
        Hazard statements  H319-H402-H302-H317-H373-H412
        Precautionary statements  P261-P280a-P305+P351+P338-P321-P333+P313-P501a-P273-P280-P260-P301+P312+P330
        Hazard Codes  Xi,N,Xn
        Risk Statements  36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22
        Safety Statements  26-36-61-36/37/39-29-22-36/37
        WGK Germany  1
        RTECS  SN5075000
        Autoignition Temperature 470 °C
        TSCA  Yes
        HS Code  29343090
        Toxicity LD50 orally in Rabbit: > 2000 mg/kg
        NFPA 704
        2 0

        Phenothiazine price More Price(16)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 88580 Phenothiazine purum, ≥98.0% (GC) 92-84-2 1kg $82.8 2019-12-02 Buy
        Sigma-Aldrich 1525707 Phenothiazine United States Pharmacopeia (USP) Reference Standard 92-84-2 500mg $352.8 2019-12-02 Buy
        TCI Chemical P0106 Phenothiazine >98.0%(GC) 92-84-2 25g $16 2019-12-02 Buy
        TCI Chemical P0106 Phenothiazine >98.0%(GC) 92-84-2 500g $32 2019-12-02 Buy
        Alfa Aesar A12517 Phenothiazine, 98+% 92-84-2 500g $36.4 2019-12-02 Buy

        Phenothiazine Chemical Properties,Uses,Production


        Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors.
        Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.

        Chemical Properties

        It is clean gray-green powder with the melting point of 185.5 ℃, boiling point of 371 ℃, 290 ℃ (5.33kPa). It is insoluble in petroleum ether, chloroform and water, and soluble in ether and hot acetic acid. It will be oxidized upon exposure to light in the air.

        side effects

        For more than a decade, phenothiazine drugs have been used to treat a variety of disorders and have proved particularly effective in the treatment of schizophrenia. Clinical experience indicates that initial extremely high dosages are necessary to effect improvement of patients with schizophrenic illnesses.
        During 1964, several sequelae have been reported following prolonged high dosage of these drugs. These recent reports refer to side effects which are apparently permanent, in contrast to earlier communications of transient deleterious effects. For example, it has been known for several years that extrapyramidal disorders occur frequently in patients taking phenothiazines; however, a reduction in dosage or cessation of medication appeared to produce a return to the normal state.
        Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.
        These medicines are available only with your doctor's prescription.
        Levoprome(R) (methotrimeprazine) is no longer available in the United States. At the end of May 1998, Immunex Corporation stopped marketing it.
        Once a medicine has been approved for marketing for a certain use, experience may show that it also is useful for other medical problems. Although these uses are not included in product labeling, phenothiazines are used in certain patients with the following medical conditions:



        22 g of diphenylamine, 8.2 g of sulfur, and 3.2 gms. of anhydrous aluminum chloride are melted together. The reaction sets 140-150° C with the rapid evolution of hydrogen sulfide; by lowerg the temperature, a few degrees the reaction can be slackened. Wen the reaction has moderated, the temperature is raised to 160° C for a time. The melt, when cool, is ground up and extracted, first with water and then with dilute alcohol. The residue consists of almost pure phenothiazine. It can be recrystallised from alcohol. Yield 93%, yellowish leaflets; m.p. 180° C.
        Preparation of phenothiazine
        Systematic organic chemistry, by W. M. Cumming, 325-326, 1937.

        Chemical Properties

        Phenothiazine is a greenish-yellow to greenish-gray crystalline substance. Slight odor and taste.

        Chemical Properties

        yellow or pale green powder


        A key component of antipsychotic and antihistaminic drugs.


        Employed in the preparation of carbazoles and piperazines,1 and charge-transfer semiconducting complexes.2


        A rigid, tricyclic thiazine useful as an electron donor.


        Insecticide; manufacture of pharmaceuticals.


        ChEBI: The 10H-tautomer of phenothiazine.

        brand name

        Nemazine (Parke-Davis).

        General Description

        Light green to steel-blue powder. Acquires a greenish-brown tint under exposure to sunlight.

        Air & Water Reactions

        Insoluble in water.

        Reactivity Profile

        Phenothiazine is slowly decomposed by sunlight. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

        Fire Hazard

        Flash point data for Phenothiazine are not available, but Phenothiazine is probably combustible.

        Safety Profile

        Poison by intravenous route. Moderately toxic to humans by ingestion. Experimental reproductive effects. An insecticide. Large doses, i.e., heavy exposure, may cause hemolytic anemia and toxic degeneration of the liver. Can cause skin irritation and photosensitization. Dangerous; when heated to decomposition or on contact with acid or acid fumes it emits hghly toxic fumes of SOx and NOx.

        Potential Exposure

        Phenothiazine is used as an insecticide; as a base for the manufacture of tranquilizers; as anthelmintic in medicine and veterinary medicine; it is used widely as an intermediate in pharmaceutical manufacture; polymerization inhibitor, antioxidant.


        UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

        Purification Methods

        Crystallise it from *benzene, toluene, hexane or Me2CO (charcoal) after boiling for 10minutes under reflux. Filter the crystals off and dry them in an oven at 100o, then in a vacuum desiccator over paraffin chips. Also recrystallise it twice from water and dry it in an oven at 100o for 8-10hours. It sublimes at 130o/1mm and has UV with at 253nm in heptane. [Beilstein


        Organosulfides are incompatible with strong acids and acid fumes; elevated temperatures; sulfur oxides and nitrogen oxides can be produced. Contact with strong reducing agents such as hydrides; azo and diazo compounds, halocarbons, isocyanates can generate heat and may form explosive hydrogen gas

        Waste Disposal

        Dissolve in combustible solvent and spray into incinerator equipped with afterburner and scrubber. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

        Phenothiazine Preparation Products And Raw materials

        Raw materials

        Preparation Products

        Phenothiazine Suppliers

        Global( 355)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Shanghai TongYuan Chemical Co., Ltd. 021-69182866-
        021-69182022 tongyuanchem@126.com China 5173 58
        Shanghai LanRun Chemical Co., Ltd. 021-69515658 ; 69515628
        021-69515998 longrunchem@163.com China 5962 50
        Shanghai XiZhi Chemical Co., Ltd. 021-69005855
        021-69005955 xizhichem@163.com China 4252 55
        JIANGSU B-WIN CHEMICAL INDUSTRY CO.,LTD. 0510-85840252- ;0510-85840251
        0510-80243668 439257802@qq.com;439257802@qq.com; China 29 58
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76
        Meryer (Shanghai) Chemical Technology Co., Ltd. 21-61259100-
        86-21-61259102 sh@meryer.com China 40268 62
        3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
        86-21-50328109 3bsc@sina.com China 15881 69
        Alfa Aesar 400-610-6006; 021-67582000
        021-67582001/03/05 saleschina@alfa-asia.com China 30163 84
        TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
        021-67121385 Sales-CN@TCIchemicals.com China 24555 81
        Beijing dtftchem Technology Co., Ltd. 010-60275820-
        010-60270825 dtftchem@sina.com; China 1403 62

        Related articles

        View Lastest Price from Phenothiazine manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2019-07-15 Phenothiazine
        US $5.00 / KG 1T AS COA 99% 100T Henan Xiangtong Chemical Co., Ltd.
        2019-06-27 Phenothiazine
        US $10.00 / KG/Tin 1KG 99% 100 career henan chemical co

        Phenothiazine Spectrum

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