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        Calcitriol

        Introduction References
        Calcitriol
        Calcitriol structure
        CAS No.
        32222-06-3
        Chemical Name:
        Calcitriol
        Synonyms
        Silkis;Calcijex;Soltriol;Toptriol;ro215535;Panbonis;1,25-dhcc;Topitriol;CALCITROL;rocaltrol
        CBNumber:
        CB0171027
        Molecular Formula:
        C27H44O3
        Formula Weight:
        416.64
        MOL File:
        32222-06-3.mol

        Calcitriol Properties

        Melting point:
        119-1210C
        alpha 
        D25 +48° (methanol)
        Boiling point:
        474.91°C (rough estimate)
        Density 
        1.0362 (rough estimate)
        refractive index 
        1.4700 (estimate)
        Flash point:
        14 °C
        storage temp. 
        2-8°C
        solubility 
        Do you have solubility information on this product that you would like to share
        pka
        14.43±0.40(Predicted)
        form 
        Solid
        λmax
        265nm(lit.)
        Merck 
        14,1644
        BRN 
        7559394
        Stability:
        Air and Light Sensitive
        InChIKey
        GMRQFYUYWCNGIN-UNVJKIGWSA-N
        CAS DataBase Reference
        32222-06-3(CAS DataBase Reference)
        SAFETY
        • Risk and Safety Statements
        Symbol(GHS) 
        GHS02,GHS06,GHS08,GHS07
        Signal word  Danger
        Hazard statements  H225-H301+H311+H331-H370-H300-H319
        Precautionary statements  P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P305+P351+P338-P337+P313
        Hazard Codes  T+,Xn,F
        Risk Statements  26/27/28-63-36/37/38-20/21/22-11
        Safety Statements  36/37/39-45-36-26-16-7
        RIDADR  UN 2811 6.1/PG 1
        WGK Germany  3
        RTECS  FZ4645000
        8-10-19
        HazardClass  6.1(a)
        PackingGroup  I
        HS Code  29061900

        Calcitriol price More Price(12)

        Manufacturer Product number Product description CAS number Packaging Price Updated Buy
        Sigma-Aldrich 1086312 Calcitriol solution United States Pharmacopeia (USP) Reference Standard 32222-06-3 5ml $438.55 2019-12-02 Buy
        Sigma-Aldrich 17936 1α,25-Dihydroxyvitamin D3 ≥97.0% (HPLC) 32222-06-3 1mg-f $1480 2019-12-02 Buy
        TCI Chemical C3078 Calcitriol >97.0%(HPLC) 32222-06-3 1mg $653 2019-12-02 Buy
        Cayman Chemical 71820 Calcitriol ≥97% 32222-06-3 1mg $68 2018-11-13 Buy
        Cayman Chemical 71820 Calcitriol ≥97% 32222-06-3 5mg $255 2018-11-13 Buy

        Calcitriol Chemical Properties,Uses,Production

        Introduction

        Calcitriol (1,25-dihydroxylcholecaldiferol) is a steroid hormone with three hydroxyl groups, which is an active metabolite and the most effective form of vitamin D. It is produced primarily in the kidney when the blood calcium level and parathyroid hormone are low. Calcitriol promotes the calcium and phosphorus absorption in the intestine, reabsorption in the kidneys. Along with parathyroid hormone, it regulates bone growth for building and keeping strong bones. Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands are not working normally, to treat secondary hyperparathyroidism and metabolic bone disease in people with kidney disease. Calcitriol may also be chemopreventive for colon and prostate cancers as it induces cell cycle arrest, cell differentiation, and apoptosis.

        References

        1. https://pubchem.ncbi.nlm.nih.gov
        2. https://medlineplus.gov
        3. http://flexikon.doccheck.com/en/Calcitriol
        4. https://en.wikipedia.org/wiki/Calcitriol
        5. https://www.webmd.com

        Description

        Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
        Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
        Calcitriol-dimensional molecular structure
        Calcitriol-dimensional molecular structure
        The above information is edited by the chemicalbook of Dai Xiongfeng.

        Chemical Properties

        White Crystalline Powder

        Uses

        Calcium regulator, anti-psoriatic

        Uses

        Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;

        Uses

        The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

        Uses

        Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]

        Definition

        ChEBI: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the li er to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.

        brand name

        Calcijex (Abbott); Rocaltrol (Roche.

        Biological Activity

        Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

        Veterinary Drugs and Treatments

        Calcitriol may be potentially beneficial in the adjunctive treatment of chronic renal disease in dogs and cats but its use is somewhat controversial, particularly the decision on how soon in the course of chronic renal insufficiency it should employed. It may also be of benefit in treating some types of dermatopathies (primary idiopathic seborrhea).

        Calcitriol Preparation Products And Raw materials

        Raw materials

        Preparation Products


        Calcitriol Suppliers

        Global( 298)Suppliers
        Supplier Tel Fax Email Country ProdList Advantage
        Chemvon Biotechnology Co., Ltd +86-21-50790412
        +86-21-50790419 marketing@chemvon.com China 358 57
        Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
        001-617-206-9595 sales@chemreagents.com United States 9919 62
        Hydragon Pharma Ltd +86(21)5021-5258, 5021-8972
        +86(21)5021-5756 market@hypharma.com China 321 58
        Zhengzhou Kangshan Biological Co., Ltd. 0371-55616640-
        0371-55616640 2584787837@qq.com; China 129 58
        Shaanxi kelkai Pharmaceutical Technology Co., Ltd 029-21485451-
        2148545164@qq.com China 376 58
        Shanghai Boyle Chemical Co., Ltd.
        86-21-57758967 sales@boylechem.com China 2926 55
        J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
        86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96505 76
        3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
        86-21-50328109 3bsc@sina.com China 15881 69
        Chembest Research Laboratories Limited 021-20908456-
        021-58180499 sales@BioChemBest.com China 5984 61
        Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
        0086-571-85864795 sales@capotchem.com China 18228 66

        View Lastest Price from Calcitriol manufacturers

        Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
        2019-09-04 Calcitriol
        32222-06-3
        US $1.00 / KG 1KG 99% Customized career henan chemical co

        32222-06-3(Calcitriol)Related Search:


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